ALS

ALS is a fatal disease that causes the degeneration of nerves that control voluntary muscle movement, like those that allow us to chew, speak, and walk. Athletes and those who have served in the military have a higher incidence of ALS, but we have not been able to find a clear causal connection for this observation.

ALS and Your Endocannabinoid System

Supplementation of the ECS with phytocannabinoids can help in two important ways:

  • Antioxidant activity--helping to clear free radicals that cause nerve destruction [27, 29]
  • Decreasing excitotoxicity (over-zealous inflammatory reactions) that causes nerve destruction [27, 36]

Activation of the CB1 receptors may slow progression of the disease. [47]

Activation of both CB1 and CB2 receptors has been shown to help with some of the symptoms of ALS. [10]

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Medical Cannabis Guidelines

There is little to no research done on cannabis as a treatment for ALS patients. However, cannabis holds promise as a tool for managing the progression of ALS based on what we know about the endocannabinoid system, phytocannabinoids, and nerve damage.

DOSING STRATEGY

Cannabis affects everyone differently. To avoid feeling overly intoxicated, start low with THC (as low as 1 mg) and gradually increase until you find the dose that works best for you. Combining CBD with THC can also help mitigate the intoxicating effects of THC.

Desired Effect

Neuroprotection (Nerve Protection)

Active Compound

THC [36], CBD [36]

Delivery Method

Pulmonary, Sublingual, Oral
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Desired Effect

Muscle Relaxation / Decreased Spasticity

Active Compound

THC [60, 69], CBD [60, 69]

Delivery Method

Pulmonary, Sublingual, Oral
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Desired Effect

Appetite Enhancement

Active Compound

THC [1, 14, 62]

Delivery Method

Pulmonary, Sublingual
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Desired Effect

Pain Relief

Active Compound

THC:CBD Balance [1, 2, 7, 19, 55, 56], THC [1, 2, 19, 55, 56], CBD [55]

Delivery Method

Pulmonary, Sublingual, Oral
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