Glaucoma is a group of diseases that damage the eye's optic nerve, and can sometimes result in loss of vision or blindness. The most common cause of nerve damage is high pressure fluid build-up inside the eye. Current treatments improve the flow of fluid, which decreases pressure and damage to the nerve.
Glaucoma and Your Endocannabinoid System
Medical Cannabis Guidelines
Cannabinoids are difficult to apply topically to the eye because they are not water soluble, so they do not absorb well into the eye. However, there is work being done to develop THC eye drops that do absorb effectively.  Currently, to control eye pressure, dosing every 3-4 hours is best if possible. To keep eye pressure at safe levels at all times, a combination of long-acting prescription medications and cannabis may give the best results.
Start low and go slow to avoid uncomfortable intoxication with THC.
Desired EffectDecrease Eye Damage
Delivery MethodInhalation, Sublingual
Desired EffectDecrease Intraocular Eye Pressure
Active CompoundTHC 
Delivery MethodPulmonary, Sublingual
Cannabis as a treatment for glaucoma became known in the 1970s due to a few highly publicized case studies like that of Robert Randall, who was the first federally recognized medical marijuana patient with glaucoma in the United States post cannabis prohibition.