Multiple Sclerosis

Multiple sclerosis (MS) is a chronic disease of the central nervous system, including the brain and spinal cord. While the exact cause of MS is unknown, immune system dysfunction plays a large role and ultimately leads to inflammation causing neurodegeneration (damage and death of nerve cells). MS is an autoimmune disease.

Multiple Sclerosis and Your Endocannabinoid System

Activation of CB1 receptors may help at many levels of disease mechanism and progression:

Activation of CB2 receptors also helps with MS mechanisms and symptoms:

  • Anti-inflammatory [11]

  • Anti-spasticity [11]

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Medical Cannabis Guidelines

THC can be a helpful medicine because it activates the CB1 receptors, however some patients are sensitive to the intoxicating effects. Including some CBD with the THC can mitigate the intoxication, and makes high-THC medicine more tolerable for some patients while also having anti-inflammatory properties of its own.

DOSING STRATEGY

Cannabis affects everyone differently. To avoid feeling overly intoxicated, start low with THC (as low as 1 mg) and gradually increase until you find the dose that works best for you. Combining CBD with THC can also help mitigate the intoxicating effects of THC.

Desired Effect

Muscle Relaxation / Decreased Spasticity

Active Compound

THC [60, 69], CBD [60, 69]

Delivery Method

Pulmonary, Sublingual, Oral
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Desired Effect

Pain Relief

Active Compound

THC:CBD Balance [1, 2, 7, 19, 55, 56], THC [1, 2, 19, 55, 56], CBD [55]

Delivery Method

Pulmonary, Sublingual, Oral
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Desired Effect

Anti-Inflammatory

Active Compound

THC [38, 55, 70], THCA [39], CBD [22, 38, 41]
B-Caryophyllene [54, 55], Myrcene [55]

Delivery Method

Pulmonary, Sublingual, Oral, Topical (localized relief)
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Desired Effect

Anxiety Relief

Active Compound

CBD [15, 16, 60], THC Low Dose [31, 43, 60]
Linalool [53], Limonene [53]

Delivery Method

Pulmonary, Sublingual, Oral
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Desired Effect

Bladder Continence

Active Compound

THC [23]

Delivery Method

Pulmonary, Sublingual, Oral
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