Rheumatoid Arthritis

In rheumatoid arthritis, the immune system, which usually protects us by attacking foreign substances like viruses and bacteria, attacks the joints instead. The attack creates inflammation that leads to swelling, pain, and destruction of tissue.

Rheumatoid Arthritis and Your Endocannabinoid System

The ECS modulates the immune system. Both CB1 and CB2 receptors have been found on immune cells, suggesting that cannabinoids play an important role in immune system regulation. [38]

The cannabinoid receptor system could become an important target for the treatment of pain and inflammation associated with rheumatoid arthritis. [61]

The ECS modulates inflammation. Manipulation of endocannabinoids and/or use of phytocannabinoids may constitute a potent treatment modality against inflammatory disorders. [38]

 

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Medical Cannabis Guidelines

THC can be a helpful medicine, however some patients are sensitive to the intoxicating effects. Including some CBD with the THC can mitigate the intoxication, and makes high-THC medicine more tolerable for some patients while also having anti-inflammatory properties of its own. Anecdotally, whole plant medicine that includes other cannabinoids, terpenes, and flavonoids has been most effective in managing rheumatoid arthritis.

 

DOSING STRATEGY

Start low and go slow with THC if you are taking it internally. Topical medicine may be used liberally without intoxication.

Desired Effect

Anti-Inflammatory

Active Compound

THC [38, 55, 70], THCA [39], CBD [22, 38, 41]
B-Caryophyllene [54, 55], Myrcene [55]

Delivery Method

Pulmonary, Sublingual, Oral, Topical (localized relief)
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Desired Effect

Inhibit Arthritis Disease Progression

Active Compound

CBD [38]

Delivery Method

Sublingual, Oral, Topical
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Desired Effect

Pain Relief

Active Compound

THC:CBD Balance [1, 2, 7, 19, 55, 56], THC [1, 2, 19, 55, 56], CBD [55]

Delivery Method

Pulmonary, Sublingual, Oral
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